MMP1 and neoplasm: Different Capsicum species including red pepper, Shishito pepper, and Cheongyang pepper were found to inhibit NO, ROS, and PGE2 in human dermal fibroblast cells, while Shishito pepper increased MMP-1 and procollagen I α1 levels, red pepper and Shishito pepper suppressed tumor TNF-α and showed protective properties against skin damage, and other spices obtained from Capsicum plants may have protective effects against skin aging (48).