We observed the involvement of PD-L1 expression in particular types of immune cells associated with CRC, including T-cells, macrophages, classical monocytes, and dendritic cells, with a proportional increase seen in the expression of cancer progression-specific USPs, including USP10, USP14, USP18, USP32, USP33, and USP39. The gene discussed is USP39; the disease is cancer.