ITGAV, a subunit of αv integrins, plays a crucial role in extracellular matrix remodeling and signal transduction, and its overexpression has been linked to epithelial–mesenchymal transition (EMT) and poor prognosis in various malignancies, including head and neck squamous cell carcinoma [44]. The gene discussed is ITGAV; the disease is head and neck squamous cell carcinoma.