Additionally, it can upregulate pro-inflammatory microRNAs (such as miRNA-34a and miRNA-146a), which can downregulate the expression of triggering receptors expressed on myeloid cells 2 (TREM2), thereby exacerbating neuroinflammation and Alzheimer’s disease pathology (Zhao and Lukiw, 2018). Here, TREM2 is linked to Alzheimer disease.