How P62 modulates the KEAP1/NRF2 axis has been elucidated in Alzheimer’s disease (Zhang et al., 2021), hypoxic–ischemic brain damage (Wang X. X. et al., 2025), and virus-induced ferroptosis in EBV-induced tumorigenesis (Yuan et al., 2022). This evidence concerns the gene SQSTM1 and early-onset autosomal dominant Alzheimer disease.