Myo-inositol has been reported to inhibit glucose absorption in the intestine and promote muscle glucose uptake in rats, whereas clinical trials have demonstrated that both myo-inositol and D-chiro-inositol possess insulin-mimetic properties and the ability to improve insulin sensitivity in metabolic conditions associated with insulin resistance in humans (Chukwuma et al., 2016; Jeon et al., 2016). Here, INS is linked to Insulin resistance.