SERPINE1 and endothelial dysfunction: Visceral adipose tissue worsens thisscenario by releasing pro-inflammatory cytokines such as tumor necrosisfactor-α (TNF-α) and interleukin-6 (IL-6), along with moleculeslike plasminogen activator inhibitor-1 (PAI-1) and angiotensinogen, whichcontribute to endothelial dysfunction and vascular remodelling [26, 27].