Similarly, Yang et al. [47] examined Th17/Treg ratios as well as IL‐17 and TGF‐β levels in 30 ITP patients and 30 matched healthy individuals, observing that ITP patients had elevated peripheral Th17 cell percentages, increased expression of HMGB1 and IL‐17, reduced proportions of Tregs, and decreased TGF‐β secretion relative to healthy subjects. Here, HMGB1 is linked to autoimmune thrombocytopenic purpura.