COL1A1 and mitral valve insufficiency: Thus, while reports of cardiovascular events with this COL1A1 variant are uncommon, some patients with the variant have been reported to have cardiac and/or vascular complications such as mitral regurgitation, aortic regurgitation, vertebral artery tortuosity, iliac artery aneurysm and dissection and coeliac trunk aneurysm and dissection, usually in adult life [12].