In induced pluripotent stem cell (iPSC)-derived dopaminergic (DA) neurons—including models carrying the LRRK2 G2019S mutation and those derived from sporadic PD—mitochondrial depolarization fails to trigger proper Miro degradation, thereby disrupting the recruitment of the Parkin-dependent autophagic machinery (Bharat and Wang, 2020; Hsieh et al., 2016). This evidence concerns the gene PRKN and Parkinson disease.