Beyond the canonical PINK1/PRKN axis, an expanding roster of PD risk and causal genes converge on mitophagy regulation (Table 1), impeding three functional tiers: (i) damage tagging and receptor recruitment, (ii) dynamical pre-processing (fission/fusion and segregation), and (iii) autophagolysosomal degradation. Here, PINK1 is linked to Parkinson disease.