Exercise reduces neuronal susceptibility to ferroptosis through (i) AMPK–ULK1-driven augmentation of mitophagy flux, (ii) PINK1/Parkin-dependent removal of iron-overloaded mitochondria, and (iii) PGC-1α-mediated stabilization of mitochondrial iron handling and antioxidant capacity—supporting mitophagy-targeted anti-ferroptotic strategies in PD. The gene discussed is PPARGC1A; the disease is Parkinson disease.