HNF4A and MODY: In many MODY-associated TF genes, homozygous LOF variants are generally thought to be embryonically lethal or result in early mortality, e.g., in GATA4 (Kuo et al., 1997), GATA6 (Morrisey et al., 1998), HNF1A (Harries et al., 2009), HNF1B (Barbacci et al., 1999), HNF4A (Chen et al., 1994), and ONECUT1 (Philippi et al., 2021).