To investigate the role of CPS1 in lung cancer progression and metastasis, we generated GEM models harboring the following alleles: (a) KP mice with wild-type Cps1 alleles; and (b) KPC mice, which are KP mice with homozygously floxed Cps1 alleles (Figure 6A and Figure S7A). Here, CPS1 is linked to lung carcinoma.