ACMSD and acute kidney injury: Alpha-amino-β-carboxymuconic acid-ε-semialdehyde decarboxylase (ACMSD) is a metabolic enzyme mainly expressed in the kidney which exacerbated AKI injury by promoting TCA cycle and inhibiting nicotinamide adenine dinucleotide (NAD+) production, whereas lack of effective intervention strategies for ACMSD-targeted therapy.