Furthermore, the levels of creatinine in IR mice were decreased (Figure 7B), the mRNA levels of KIM-1 and NGAL in AKI kidney were downregulated (Figure 7C, D), the degree of renal injury was considerably rescued, as well as the glycogen deposition and the injury score when pretreatment with RNAi@ROS-CVs (Figure 7E-G). Here, HAVCR1 is linked to acute kidney injury.