Furthermore, the levels of lipid oxidation and free iron in AKI kidneys were also substantially decreased under the treatments of RNAi@ROS-CVs NPs (Figure 6L and 6M), and the indicators of inflammation such as IL-6, IL-1, CXCL-2, CXCL-8 and CXCL-12 were decreased (Figure S18A-E), as well as the mRNA level of injury-related indicators such as KIM-1 and neutrophil gelatinase-associated lipocalin (NGAL) (Figure S18F, G). Here, HAVCR1 is linked to acute kidney injury.