Staining of brain metastases from NSCLC patients revealed more clustered reactive astrocytes, GAS6 infiltration, and accompanying dense vascularity in tissues with CD146 high expression compared to tissues with CD146 low expression (Figure 6E), and a similarity was observed in the intracranial tumors from mice implanted with BrM3-CSCs (Figure S5J). Here, MCAM is linked to non-small cell lung carcinoma.