While Chen et al. shown that lactate binds to NSUN2-K356 to facilitate the capture of m5C-modified RNAs in colorectal cancer 7, whether lactylation at NSUN2-K692 similarly aids in the m5C modification of CDCP1 and STC1 remains an intriguing avenue for further investigation. The gene discussed is NSUN2; the disease is colorectal cancer.