Although immunohistochemical staining (such as Mouse Double Minute 2 homolog [MDM2] and Cyclin-Dependent Kinase 4 [CDK4) or molecular testing [such as MDM2 amplification by Fluorescence in situ Hybridization (FISH)] can aid in distinguishing WDLPS from lipoma, these were deemed unnecessary due to classic histological features: uniform adipocyte size, absence of lipoblasts, nuclear atypia, mitotic figures, and necrosis, along with the lesion's well-circumscribed nature and lack of radiological suspicion. This evidence concerns the gene CDK4 and lipoma.