In aging-related cardiovascular diseases, activation of the SIRT2–LKB1–AMPK signaling axis ameliorates cardiac hypertrophy in murine models [3], while the SIRT2–p66shc–mROS axis improves vasomotor dysfunction (e.g. impaired vascular contraction-relaxation) in aged mice [4]. Here, SIRT2 is linked to cardiovascular disorder.