For example, the downregulation of miR-1-3p and miR-432-5p was shown to drive heart failure and myocardial ischemic injury by regulating pathways related to oxidative stress, while the upregulation of miR-1246 promotes VEGF signalling associated with angiogenesis, proliferation, and vascular remodelling [59–62]. This evidence concerns the gene VEGFA and heart failure.