Inhibited NF-κB, TLR4/MyD88 and p38 MAPK signaling pathwayReduced the release of pro-inflammatory factors (TNF-α, IL-6, IL-1β)Activated AMPK/mTOR pathwayInhibited AGEs/RAGE signaling to reduce oxidative stress and inflammation in diabetic nephropathyInhibited NOX4 expression to reduce the level of oxidative stressInhibited TGF-β1 pathway, reduce renal fibrosis and inflammation. Here, MYD88 is linked to renal fibrosis.