As a result, the two Gemini-like NPs in hydrogel cut CAF-secreted CCL2 by 72%, reduced CD44+CD133+ CSCs by 68%, and tripled intratumoral granzyme-B+ CD8+ T cells, yielding almost complete tumor regression in 90% of mice (n = 10), which achieved a remarkable regression of the chemo-resistant tumors. Here, CD44 is linked to neoplasm.