TGFB1 and neoplasm: In the desmoplastic pancreatic model, APTEDB-(NS-TAX@Lipo-VAC) (size nearly 200 nm) could targeted accumulate in the tumor region after blood circulation and deliver VAC in CAFs to specifically act on TGF-β signaling, leading to significantly reduced expression of ECM proteins in the tumor stroma after collapse of the liposomes.