In their study, the small nanospheres carrying TAX (NS-TAX) were encapsulated into the hydrophobic core of VAC-loaded liposomes (Lipo-VAC), and a peptide (APTEDB) targeting the fibronectin extra domain B (EDB) was used to be modified on the outer surface of NPs in order to anchor the NPs to abundant tumor-associated fibronectin in cancer stroma. This evidence concerns the gene FN1 and neoplasm.