Notably, selective suppression of actinin alpha 1 in CAFs by oroxylin A inhibits their contractility and matrix remodeling capacity, leading to a remarkable decrease of breast cancer lung metastasis owing to blockade of FAK/Src/JAK2/STAT3 signaling, reduced CCL2 secretion, and subsequent disruption of CAF-tumor cell crosstalk and metastatic niche formation 106. Here, CCL2 is linked to neoplasm.