For example, in a lung cancer (LC) relapse model, butyrate derived from Roseburia inhibited HDAC2, increased H3K27 acetylation at the H19 promoter, and induced M2 macrophage polarization, thereby increasing the expression of H19 in tumor cells and promoting lung cancer metastasis 104. The gene discussed is H19; the disease is laryngotracheoesophageal cleft.