Regarding cell death, butyrate promotes apoptosis by upregulating pro-apoptotic proteins (Bax, p53) and downregulating Bcl-2 116,117, while also inducing ferroptosis in endometrial cancer, CRC, and PDAC cells through regulation of RBM3, CD44, and SLC7A11 expression balance as well as lipid metabolism 118-120. This evidence concerns the gene SLC7A11 and colorectal carcinoma.