Interestingly, a recent study demonstrated that CHK2-mediated phosphorylation of NRF2 at serine 566 and serine 577 enhances its transcriptional activity and antioxidant capacity without affecting its expression 57, whether the post-translational modification function of NRF2 also plays a role in neurodegenerative diseases, remains to be elucidated. The gene discussed is NFE2L2; the disease is neurodegenerative disease.