In addition to tumor cells evolving resistance to cuproptosis, high cuproptosis signatures in the TME are closely linked to the immunosuppressive TME as evidenced by three key observations: First, elevated cuproptosis-related genes (e.g., SLC31A1, FDX1) positively correlate with immunosuppressive cytokines, cells and immune checkpoint molecules while predicting poor prognosis. Here, SLC31A1 is linked to neoplasm.