CR2 and neoplasm: Consistently, spatial transcriptome and mIHC analyses using adjacent sections show that TLS regions containing MIF+ tumor cells (SOX2+) are enriched with exhausted T cells (CD3+PD-1+TIM-3+) and exhausted B cells (CD20+CD21-CD27-PD-1+), indicating an impaired B-cell immune response (Figure 6A, 6C-E).