In contrast, non-responders exhibited persistent MIF-CXCR4-mediated crosstalk between GC B cells (CXCR4hiCD83loCD86lo dark-zone subset) and cholesterol-biosynthetic tumor cells (pan-CK+, HMGCRhi) across treatment timepoints (Figure 5B, S9C). Here, CXCR4 is linked to neoplasm.