For instance, a tumor-targeted bacterial biohybrid (named eVNP@AuNFs) down-regulates CD47 and heat shock protein 90 (HSP90) via short hairpin RNA (shRNA) plasmids to block “don’t eat me” signals, while its gold nanoparticle component mediates second near-infrared (NIR-II)-triggered PTT to induce ICD markers like calreticulin, thereby synergistically boosting macrophage phagocytosis and systemic immunity in 4T1 tumors [112]. The gene discussed is CD47; the disease is neoplasm.