EGF and ovarian carcinoma: Similarly, in ovarian cancer, M2-like TAMs secrete epidermal growth factor (EGF) to suppress the metastasis-restraining long noncoding RNA (lncRNA) LIMT via EGF receptor (EGFR)–ERK signaling, thereby accelerating proliferation, migration, and EMT; importantly, pharmacologic EGFR blockade or enforced LIMT expression reverses these protumoral effects [32].