Similarly, homogeneous Polyporus polysaccharide (HPP) repolarizes TAMs in bladder cancer via NF-κB/NLRP3 signaling, creating an anti-TME that indirectly induces autophagy in cancer cells by inhibiting the PI3K/Akt/mTOR pathway in macrophage–tumor cocultures [82,83]. The gene discussed is NFKB1; the disease is neoplasm.