In colorectal and breast cancers, pharmacologic suppression of cancer stemness using salinomycin, SB-431542, JIB-04, or napabucasin reduces Wnt/β-catenin, TGF-β, histone demethylase, and STAT3 signaling, thereby depriving TAMs of tumor-derived instructive cues and reprogramming them from an M2 to an M1 phenotype. The gene discussed is TGFB1; the disease is neoplasm.