NLRP3 and neoplasm: These include IL4I1+ macrophages that engulf apoptotic cells in high-turnover regions and predict favorable prognosis in colon cancer, SPP1+ macrophages confined to hypoxic or necrotic tumor cores and associated with poor outcome, FOLR2+ macrophages embedded within plasma cell niches, and NLRP3+ macrophages that colocalize with neutrophils to drive inflammasome activation [23].