Overall, 60 studies were eligible for inclusion: 25 single arm clinical trials,5, 14, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51 28 controlled clinical trials,4, 9, 10, 11, 18, 19, 20, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72 and seven multicentre real world studies,73, 74, 75, 76, 77, 78, 79 comprising 4633 patients with advanced BRAF-mutated colorectal cancer (see supplementary table S7). Here, BRAF is linked to colorectal cancer.