Collectively, Verbascoside’s efficacy arises through its multi-tiered action of suppression of the HIF-1α-LOX/LOXL2 pathway within endothelial cells, normalization of glucose metabolism and endothelial paracrine secretome thereby relieving oxidative and fibrotic stress on mesangial cells, and measurable alleviation of DN manifestations. Here, HIF1A is linked to liver dysplastic nodule.