In two independent immunotherapy single‐cell datasets, GSE206325 and Liu_HCC from the scICB database, the expression of UQCRH and PPM1G was significantly lower in the responder group compared with the non‐responder group (Figure 9D), and the seven genes score was significantly lower in the responder group compared with the non‐responder group (Figure 9E), suggesting these genes and the seven genes score may be involved in mediating resistance to immunotherapy. The gene discussed is PPM1G; the disease is hepatocellular carcinoma.