SMARCA1 and male infertility: The process is tightly coordinated by Chromatin Remodeling Complexes (CRCs)—notably members of the SWI/SNF, ISWI, CHD, and INO80 families—that reposition or evict nucleosomes in an ATP-dependent manner The essential nature of CRCs is exemplified by BRG1, the catalytic ATPase of the SWI/SNF complex, whose deficiency results in incomplete histone removal and male infertility [25].