For example, Sakane et al. [70] identified differential abundance of proteins, including fibulin-3 and gelsolin, in EVs from patients with advanced fibrosis, while Geng et al. [71] observed elevation of hepatocyte-associated proteins such as epithelial cell adhesion molecule (EpCAM) and ITGA3 in EVs from precision-cut liver slices of patients with cirrhosis, with upregulated proteins enriched in complement and coagulation cascades and downregulated proteins associated with xenobiotic and drug metabolism pathways. The gene discussed is EFEMP1; the disease is fibrosis.