EFEMP1 and Cirrhosis: For example, Sakane et al. [70] identified differential abundance of proteins, including fibulin-3 and gelsolin, in EVs from patients with advanced fibrosis, while Geng et al. [71] observed elevation of hepatocyte-associated proteins such as epithelial cell adhesion molecule (EpCAM) and ITGA3 in EVs from precision-cut liver slices of patients with cirrhosis, with upregulated proteins enriched in complement and coagulation cascades and downregulated proteins associated with xenobiotic and drug metabolism pathways.