The role of SIRT6 in lipid metabolism is highly context dependent and varies by cell type, metabolic status, and disease environment.32,44,45 While SIRT6 is widely recognized as a tumor suppressor and lipid reducer in certain contexts—such as in the liver, where it suppresses lipogenic pathways46 or promotes fatty acid β-oxidation,32 and in cardiomyocytes, where it inhibits PPARγ-mediated fatty acid uptake47—emerging evidence underscores its functional diversity. This evidence concerns the gene PPARG and neoplasm.