PLA2G7 and cancer: Whole-cell and plasma membrane lipidomic analysis of adipogenesis showed that changes in LPE and other lipids in cells are closely related to adipogenic differentiation.16 The lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor darapladib remodels lipid metabolism by reducing LPE species, thereby sensitizing cancer cells to ferroptosis.17 These studies clearly suggest that LPE exerts the crucial roles in the regulation of lipid metabolism and adipogenesis and is implicated in tumorigenesis and progression.