CAPZA1 and neoplasm: Histological analysis demonstrated that knockdown of CAPZA1 significantly inhibited tumor cell proliferation (Supplementary Fig. 9o), lipid deposition (Supplementary Fig. 9p, q), and ACAT2 expression (Supplementary Fig. 9r) in xenograft tumors, whereas OSS-128167 treatment further enhanced these inhibitory effects (Supplementary Fig. 9o–r).