This protumorigenic activity challenges the conventional view of SIRT6 as a tumor suppressor in renal cancer and underscores the metabolic adaptability of deacetylases within distinct tumor microenvironments.53,54 The increased cholesterol esterification driven by this axis facilitates lipid droplet formation, which is a hallmark of ccRCC progression. This evidence concerns the gene SIRT6 and nonpapillary renal cell carcinoma.