Parathyroid hormone-related protein (PTHrP) secreted by ccRCC cells acts on the PAT, triggering a process whereby the white, energy-storing fat transforms into brown, energy-burning fat, which in turn fuels ccRCC progression.10 These suggest that the PAT and ccRCC form a mutually reinforcing partnership—the tumor directs the fat to change, and the changed fat, in turn, provides the “fuel” the tumor needs to thrive. Here, PTHLH is linked to neoplasm.