Notably, bioinformatic analyses of ccRCC datasets indicate that CAPZA1 overexpression is not only an indicator of poor prognosis but also correlates clinically with advanced disease stage and reduced survival, positioning it as a potential biomarker.25 However, the functional significance of this observation and the mechanistic basis underlying the role of CAPZA1 in ccRCC pathogenesis remain completely unexplored. The gene discussed is CAPZA1; the disease is nonpapillary renal cell carcinoma.