Parathyroid hormone-related protein (PTHrP) secreted by ccRCC cells acts on the PAT, triggering a process whereby the white, energy-storing fat transforms into brown, energy-burning fat, which in turn fuels ccRCC progression.10 These suggest that the PAT and ccRCC form a mutually reinforcing partnership—the tumor directs the fat to change, and the changed fat, in turn, provides the “fuel” the tumor needs to thrive. Here, PTHLH is linked to nonpapillary renal cell carcinoma.