TARDBP and Huntington disease: Clinical studies of cortical and striatal postmortem tissues have shown TDP-43 aggregation in cases with HD as well as mHTT inclusions in a few cases with both intermediate (27–35 CAG repeats) or reduced penetrance (26–39 CAG repeats) HTT alleles and motor neuron disease, suggesting a potential overlap in the neuropathology of these diseases [12, 13, 119].