INSM1 and glioblastoma: To validate the functional role of INSM1 in GBM, we first applied the ontology-based GBM classification scheme to INSM1 RNAi PRO eNSCs in vitro, which demonstrated a substantial decrease in the fraction of glycolytic/plurimetabolic (GPM) cells compared to control PRO cells (Fig. 5G), suggesting that INSM1 also reprograms metabolism in PRO eNSCs.