Clinical studies have demonstrated that Lingguizhugan Decoction effectively ameliorates IR in overweight/obese NAFLD patients by modulating the DNA N6-methyladenine modification of protein phosphatase 1 regulatory subunit 3 A (PPP1R3A) and autophagy-related 3 (ATG3) [216]. The gene discussed is PPP1R3A; the disease is metabolic dysfunction-associated steatotic liver disease.