Icariin [140] and magnoflorine [141], Sappanone A [142], Guizhi Shaoyao Zhimu Decoction [143] have also been found to affect RA-related inflammation through the TRIB1/TLR2/NF-κB pathway and the PI3K/Akt/NF-κB pathway, respectively. The gene discussed is AKT1; the disease is rheumatoid arthritis.