AKT1 and rheumatoid arthritis: Sinomenine [157], imperatorin [158], rutin, asperosaponin VI [159], Fuhu Lijie Tang [160], and berberine [161] inhibit key factors in the MAPK pathway, such as p-ERK, p-P38, p-STAT-1/3, p-PI3K, p-Akt, p-JNK, p-IκB, p-NF-κB, and β-catenin, thereby improving inflammation in RA.