Importantly, compared to castration-sensitive prostate cancer (CSPC) tissues, CRPC tissues exhibited significantly higher mRNA levels of SNRPA, NDUFS8, and NDUFS9 (Fig. 8O–Q), as well as increased ATP contents (Fig. 8R) and mtDNA levels (Fig. 8S). The gene discussed is NDUFS8; the disease is Familial prostate cancer.