BRCA1 and ovarian cancer: We assessed PLK1 and WEE1 mRNA expression in ovarian cancer, predominantly HGSOC, and found that both genes were significantly overexpressed (n = 426) compared with normal ovarian tissues (n = 88) in the TCGA and GTEx datasets (Supplementary Fig. S1A), and were positively correlated with each other and with BRCA1/2 expression (Supplementary Fig. S1B–D).