As a result, we can see that BEX3, RPLP0, GAPDH, TUBA1C, HILPDA, PYCR1, CDC42EP1, CBX2, SPP1, TNFAIP6, AQP9, EIF4EBP1, DEFB4A gene is significantly up‐regulated in recurrent NPC tissue, while SCIN, HSPB8, RPTN, TIMD4, C7, GPR174, ZMAT1, RASGRP3, CR1, ZNF860, ZNF813, FAM214A, RALGPS2, ANGPTL1, KMO gene is significantly down‐regulated. The gene discussed is ZMAT1; the disease is nasopharyngeal carcinoma.