Mechanistically, the classical tumour‐suppressive functional way of PLA2R1 was that the hypermethylation induced the activation of the kinase Janus‐kinase 2 (JAK2) and oestrogen‐related receptor a (ERRa)‐controlled mitochondrial proteins, and increased the accumulation of reactive oxygen species which led to apoptosis and senescence [59, 60]. This evidence concerns the gene PLA2R1 and neoplasm.