As a result, we can see that BEX3, RPLP0, GAPDH, TUBA1C, HILPDA, PYCR1, CDC42EP1, CBX2, SPP1, TNFAIP6, AQP9, EIF4EBP1, DEFB4A gene is significantly up‐regulated in recurrent NPC tissue, while SCIN, HSPB8, RPTN, TIMD4, C7, GPR174, ZMAT1, RASGRP3, CR1, ZNF860, ZNF813, FAM214A, RALGPS2, ANGPTL1, KMO gene is significantly down‐regulated. This evidence concerns the gene CDC42EP1 and nasopharyngeal carcinoma.