In addition, to explore the differences between recurrent NPC and primary NPC, we performed DEseq2 difference analysis on these two groups of samples, and found that 599 lncRNAs were significantly different, of which 250 were up‐regulated and 349 were down‐regulated (Figure S2A, Table S13), the top 15 genes such as AC122108, GPRC5D‐AS1, LINC02081, RMRP, AC011294, FAM3D‐AS1 and LINC00472, AC124016, LINC01291, AC007336, DPYD‐AS2, CLMAT3 with the most significant changes in expression are shown in the heatmap (Figure S2B). The gene discussed is GPRC5D; the disease is nasopharyngeal carcinoma.