Although it is difficult to correlate the DURS1-associated phenotypes to a specific gene because of its genetic heterogeneity, the overlapping phenotypes of Traboulsi syndrome and DURS1 are striking and the role of ASPH in DURS1 should be investigated. The gene discussed is ASPH; the disease is facial dysmorphism-lens dislocation-anterior segment abnormalities-spontaneous filtering blebs syndrome.