ASPH and facial dysmorphism-lens dislocation-anterior segment abnormalities-spontaneous filtering blebs syndrome: The three reported pathogenic Traboulsi syndrome–associated SNPs, corresponding to the R735W (1, 24), R735Q (12, 23), and R688Q AspH (11), were introduced by standard methods using a construct of human wt AspH encoding for His6-AspH315–758 (52).