ASPH and facial dysmorphism-lens dislocation-anterior segment abnormalities-spontaneous filtering blebs syndrome: Thus, it is, at least in principle, possible that the Traboulsi syndrome–associated variations in the AspH active site alter the consensus mechanism for 2OG oxygenases, i.e., they perturb the preferred ordered sequential binding of 2OG, then substrate, and then O2 to the active site (162, 163).