ASPH and facial dysmorphism-lens dislocation-anterior segment abnormalities-spontaneous filtering blebs syndrome: The combined results indicate that the effects of substitutions in the AspH active site and TPR domain on the reactivity with 2OG derivatives vary with the 2OG substitution pattern; thus, there is likely scope to design improved 2OG derivatives that may fully rescue the activity of Traboulsi syndrome–associated AspH variants.