Although the R735Q AspH kcatapp/Kmapp value for 2OS was ∼250-fold lower than that of wt AspH for 2OG, the results clearly reveal the potential of (naturally occurring) 2OG derivatives for, at least, partially rescuing the activity of Traboulsi syndrome–associated AspH variants. This evidence concerns the gene ASPH and facial dysmorphism-lens dislocation-anterior segment abnormalities-spontaneous filtering blebs syndrome.