AspH may also catalyze other reactions in addition to EGFD hydroxylations, including, e.g., EGFD disulfide isomerizations (47); it is thus of interest to investigate whether Traboulsi syndrome–associated variations in the AspH active site have an impact on the EGFD disulfide connectivity, although this is challenging to do in cells. The gene discussed is ASPH; the disease is facial dysmorphism-lens dislocation-anterior segment abnormalities-spontaneous filtering blebs syndrome.