Notably, the levels of activity observed for R735Q and, in particular, R735W AspH with the 2-oxoacids 13, 15, and 16 are higher than those with the methionine transamination product 14 (Table 3), indicating that optimized 2-oxoacids might be identified that efficiently rescue the activity of Traboulsi syndrome–associated AspH variants. Here, ASPH is linked to facial dysmorphism-lens dislocation-anterior segment abnormalities-spontaneous filtering blebs syndrome.