Compared with unaffected controls, patients with PD displayed significantly higher plasma levels of HexCer (6270.1 ± 1862.6 nM vs. 5734.3 ± 1648.5 nM, Padj = 0.004), Hex3Cer (587.9 ± 189.6 nM vs. 539.2 ± 184.1 nM, Padj = 0.004), and GM3 (2413.8 ± 705.0 nM vs. 2210.5 ± 592.2 nM, Padj = 0.004), whereas Hex2Cer and Cer showed no differences (Fig. 2B). This evidence concerns the gene CBLN1 and Parkinson disease.