Comparison of the diagnostic performance of ER‐negative, HER2‐positive, 5th percentile MTRasym value, and multivariate prediction model in predicting pCR after NAC in breast cancer showed that the diagnostic performance of the multivariate prediction model was significantly superior to that of each individual predictor (all p values < 0.001) (Table 5, Figure 5). Here, ESR1 is linked to breast cancer.