Building on this mechanism, translational medicine research has proposed three categories of interventional strategies: First, non‐specific release inhibitors typified by EP block the HMGB1‐TLR4/NF‐κB positive feedback loop, significantly attenuating post‐traumatic acute lung injury, hemorrhagic shock‐induced hepatic injury, radiation‐induced pulmonary fibrosis, and sepsis‐associated immunosuppression in animal models. Here, HMGB1 is linked to Sepsis.