In hypoxic glioblastoma, HMGB1 upregulates the HOXD9 → PFKFB3 axis in an autocrine manner, elevates fructose‐2,6‐bisphosphate levels, allosterically activates 6‐phosphofructo‐1‐kinase (PFK‐1), accelerates glucose‐to‐lactate flux, and suppresses mitochondrial oxygen consumption, thereby inducing a “glycolytic lock” phenotype [106]. Here, HMGB1 is linked to glioblastoma.