Second, HMGB1 reshapes drug efflux and the DNA repair landscape: in cisplatin‐resistant NSCLC cell lines, cytoplasmic HMGB1 colocalizes with P‐glycoprotein (P‐gp) and co‐upregulates MRP and lung resistance‐related protein (LRP) expression, enhancing platinum drug extrusion [40]. The gene discussed is HMGB1; the disease is non-small cell lung carcinoma.