To elucidate TMEM106A's role in the glioma microenvironment, we performed deconvolution of bulk RNA‐seq datasets to quantify 12 cellular compartments: tumor (tumor‐stem‐like, tumor‐proliferative‐stem‐cell, differentiated‐tumor‐cell), stromal (pericytes, endothelial cells, oligodendrocytes, fibroblasts), and immune (myeloid, dendritic cells, T cells, B cells, granulocytes). Here, TMEM106A is linked to central nervous system cancer.