Gene set enrichment analysis (GSEA) revealed that pro‐inflammatory and cytokine signaling pathways were significantly enriched in TMEM106A‐overexpressing gliomas, most prominently the interleukin‐6/Janus kinase/Signal Transducer and Activator of Transcription 3 (IL‐6/JAK/STAT3) pathway and the Tumor Necrosis Factor‐alpha/Nuclear Factor kappa B (TNF‐α/NF‐κB) pathway. Here, STAT3 is linked to central nervous system cancer.