Nonetheless, limited prior evidence has linked the TMEM106 locus to glioma: an integrative TCGA multi‐omics classifier identified a DNA‐methylation block annotated to TMEM106A among features separating GBM from lower‐grade gliomas [11], and earlier GBM cancer‐stem‐cell datasets measured TMEM106A without reporting it as a significant hit [12]. This evidence concerns the gene TMEM106A and central nervous system cancer.