In the differential analyses between normal and tumor tissues, we examined the updated glioma classification, encompassing all gliomas, IDH‐wildtype astrocytomas (IDHwt), IDH‐mutant astrocytomas (IDHmu), and oligodendrogliomas (Oligo), to assess the mRNA expression levels of TMEM106A, TMEM106B, and TMEM106C. This evidence concerns the gene TMEM106B and central nervous system cancer.