As a consequence, higher fractions of myeloid cells necessarily coincide with relative reductions in other compartments (e.g., tumor‐stem‐like or non‐myeloid stromal lineages), and many of the observed correlations between TMEM106A and non‐myeloid compartments are likely mediated, at least in part, by their covariance with the myeloid fraction rather than reflecting fully independent biology. This evidence concerns the gene TMEM106A and neoplasm.