In line with this, immunosuppressive M2‐polarized tumor‐associated macrophages (TAMs) have been shown to paradoxically foster tumor expansion via an NF‐κB/IL‐6/STAT3 positive feedback loop [25], wherein macrophage‐derived cytokines (e.g., IL‐6) activate STAT3 in tumor cells and further skew macrophages toward a tumor‐promoting phenotype. The gene discussed is IL6; the disease is neoplasm.