Consistent with (Figure 10), the “PD‐1–on” specificity of the immunophenoscore (IPS) signal indicates that TMEM106A‐high tumors in IDH‐wildtype astrocytoma align with an inflamed, macrophage‐dominated state that is plausibly compatible with PD‐1–axis benefit. This evidence concerns the gene TMEM106A and astrocytoma (excluding glioblastoma).