To illustrate how TMEM106A could be incorporated into risk stratification, we next fit a multivariable Cox proportional‐hazards model in the TCGA glioma cohort with overall survival as the endpoint and covariates TMEM106A expression (per‐tumor log2[TPM + 1] z‐score), age, Karnofsky performance score, WHO grade, gender, radiotherapy, and chemotherapy, and visualized this model as a points‐based nomogram (Figure 8E). Here, TMEM106A is linked to central nervous system cancer.