Other off-label indications under Health Canada included Myasthenia Gravis, Multiple Sclerosis, repeated Implantation Failure, Antiphospholipid syndrome, Rheumatoid arthritis, Pemphigoid Gestationis, Anti-Ro antibodies, HDFN, Antibody-mediated rejection (renal transplant), Chronic Villitis, Small fiber polyneuropathy, Idiopathic Angioedema, and Autoimmune Necrotizing Myositis. The gene discussed is CALR; the disease is multiple sclerosis.