MAPT and tauopathy: Conversely, in cases of tauopathies driven by the splice-site mutations in MAPT, which alters the ratio of 3-microtubule repeat tau (3 R-Tau) to 4 R-Tau and sufficient to drive frontotemporal dementias, elevated tau may mean that LPS-induced model may be increasing the production of more tau in IL-1RAcPb knockout mice.