MAPT and Alzheimer disease: Together with the rs12053868 SNP reported in Ramanan et al., we could speculate that there might be a relationship between the total tau levels (neuroprotection/preventing neuronal atrophy) we observed in our study in LPS-injected IL-1RAcPb knockout mice and a likelihood of upregulation of IL-1RAcP/IL-1RAcPb activity in patients carrying the rs12053868 AD risk SNP.