In our cross-species comparisons, we identified notable gene overlaps between canine and human TC transcriptomes, including KIT, DUSP4, ETV4, INSR, and VEGFA in FTC and FOXA1, RET, ETV4, DUSP4, CALCA, CALCB, GFRA4, and SEMA3E in MTC. The gene discussed is DUSP4; the disease is medullary thyroid gland carcinoma.