CHEK1 and cancer: Repeating the TDS correlation analyses using only FTC samples (Fig. 2D, Supplementary Data 3) revealed key cancer genes that anti-correlated with TDS within the FTC cohort including KIT (Fig. 2E), CHEK1, and PTPRK. In contrast, a tumor angiogenic factor, ADM2 (Adrenomedullin 2), was associated with a high TDS (Fig. 2F).