After demonstrating that CSNK1D (AA314-415) can promote the stable regulation of the GLI1-BCL2 axis in the CSNK1D-SHH-PTCH1 complex, we directly searched for CSNK1D-related drugs from DGIDB and differently expressed genes between CSNK1D high vs low group by dividing the TCGA HNSCC tumor patients based on the expression of CSNK1D-related drugs in L1000FWD. Here, GLI1 is linked to head and neck squamous cell carcinoma.