IDUA and Scheie syndrome: Mucopolysaccharidosis type I (MPS I), is an autosomal recessive lysosomal storage disease caused by a deficiency of α-L-iduronidase (IDUA, EC 3.2.1.76) due to mutations in the IDUA gene, and affects ~ 1–9:1,000,000 live births [1, 2].