TLR2 and brain ischemia: Indeed, evidence points to shared roles of TLR2, gangliosides and cholesterol in disorders characterized by inflammation, such as insulin resistance, cancer and neurodegeneration; some of these insights are derived from research done in TLR2-deficient mice whose phenotype includes altered energy metabolism, increased susceptibility to neoplasms, unregulated tissue responses in brain ischemia, neurobehavioral dysfunctions56–60.