In RPR2 SCLC mice, non-NE tumor cells showed high NOTCH signaling activity and are relatively less proliferative, whereas NOTCH-inactive NE tumor cells are highly proliferative16, similar to our observation (Fig. 1i, j), which might be the reason why Cracd-depleted preSC cells displayed cell hyperproliferation in vitro (Supplementary Fig. S1a-c). Here, CRACD is linked to neoplasm.