In intestinal epithelial and colorectal cancer cells, CRACD loss triggers the release of β-catenin from the cadherin-catenin-actin complex, inducing β-catenin-transactivated WNT target genes20, including MYC, which might explain WNT and MYC activation in non-NE cells of CRPR2 tumors. The gene discussed is MYC; the disease is colorectal cancer.