CRACD and small cell lung carcinoma: Since Cracd KO induces SCLC-like morphological changes in preSC cells (Supplementary Fig. S2b), we investigated whether CRACD depletion is sufficient to drive cell plasticity by single-cell RNA sequencing (scRNA-seq) of preSC allograft tumors derived from preSC cells (Cracd WT or KO) (Supplementary Fig. S2f, S2g–j.