We conducted a comparative analysis of signaling pathways associated with SCLC tumorigenesis: NOTCH (Hes1, Dll1, Jag1, Notch1/2/3), MYC (Myc, Mycl, Ndrg1), WNT (Ccnd1, Axin2, Wnt4, Wnt5a, Wnt7), and EMT (Zeb1/2). This evidence concerns the gene DLL1 and small cell lung carcinoma.