TCGA analysis also yielded similar results, showing elevated expression of HOTAIR and EZH2 in advanced EC (Stage III&IV) compared to early-stage cancer (Stage I&II), with a positive correlation between HOTAIR and EZH2 expression (r = 0.18, P = 0.019) (Supplementary Fig. S1A–C). This evidence concerns the gene EZH2 and cancer.